Welcome to the DOSI Lab at the Beckman Laser Institute
DOSI is a technology designed to "see" metabolic tissue function and tissue architecture below the surface. DOSI provides high spectral resolution (as with MRS) with a low spatial resolution of functional quantities (as with PET) using a handheld probe and portable interface (as with ultrasound). For more information, check out the DOSI wiki to learn about instrumentation, theory, and even a little history about DOSI.
We are heavily engaged in translational research, where we conceptualize, construct, and test unique instruments designed to solve important medical/biomedical problems.
The DOSI Lab at UC Irvine is part of a NIH-supported technology P-41 Technology center (National Center for Research Resources, NCRR) designed to provide our technologies to other researchers: to learn more please see the Laser Medical and Microbeam Program (LAMMP).
For more information about DOSI within that program, please see the DOSI page in LAMMP. Collaborations are welcome and strongly encouraged at any level along the translational research pipeline.
We are also part of another NIH-supported multi-center network, the Network for Translation in Optical Imaging. This network, composed of academic centers at UC Irvine, UC San Francisco, Dartmouth, Harvard (MGH) and U Penn, is now engaged in a multi-center clinical trial that features DOSI technology. For more information, check out the American College of Imaging Radiology Imaging Network study site.
DOSI Standing Meeting Schedule
Weekly Planning Meeting: Monday 1-2 pm, BLI Conference Room
The purpose of this meeting is to discuss research plans for the week - experiments, grants, visitors, conferences, papers - anything that requires lab resources.
Scientific Discussion Meeting: Wednesday 1-2 pm, BLI Conference Room
The purpose of this meeting is to discuss research topics relevant to DOSI.
Tumor Board, Fridays 12-1:30 pm, BLI Library
The purpose of this meeting is to discuss breast cancer topics related to the ACRIN Clinical Trial, such as patient data and quality control measures.
Latest DOSI News
04/04/2012 Tomorrow Dr. Bruce Tromberg and Dr. Albert Cerussi will be presenting the DOSI lab miniature instrument to a selection of representatives from the UC system. They recently received a "UC Discovery Grant" designed to accelerate lab technologies into the marketplace.
01/15/2012 Beckman Laser Institute High school Summer Clinic is open for applications. Please check out our latest information and complete your application today. Spots tend to fill up quickly and there are a limited number of openings.
10/05/2011 New DOSI paper in JBO: Breast cancer spatial heterogeneity in near-infrared spectra and the prediction of neoadjuvant chemotherapy response
10/05/2011 Added a tutorial about spectrometer basics from B & W Tek. Currently it has 6 parts covering the main components of a spectrometer.
09/30/2011 ACRIN Clinical trial has reached our 6th patient. We now have 2 of the 5 sites in active enrollment, with more on the way!
11/30/2010 Congratulations to Jing Liu - he successfully defended his Ph.Thesis in Physics on new image reconstruction methods for diffuse optical spectroscopic imaging in a tough situation: broadband wavelengths and in reflectance. Great job and a bright future for Jing, I mean Dr. Liu!
10/21/2010 ACRIN is a go ... the multi-center clinical trial has an official study number, ACRIN #6691. For more information, check out the ACRIN page link for the study.