Follow the links to the papers in Pubmed (when applicable) or at the Journal site itself.



  1. O’Sullivan, Thomas D.,  Albert E. Cerussi, B. J. Tromberg and D. J. Cuccia, “Diffuse optical imaging using spatially and temporally modulated light,” J. Biomed. Opt. 17(7), (2012).
  2. S. H. Chung, H. Yu, M.-Y. Su, A. E. Cerussi and B. J. Tromberg, “Molecular imaging of water binding state and diffusion in breast cancer using Diffuse Optical Spectroscopy and Diffusion Weighted MRI,” J. Biomed. Opt. 17(7), 071304, (2012).
  3. S. Ueda, D. Roblyer, A. Cerussi, A. Durkin, A. Leproux, Y. Santoro, S. Xu, T. D. O’Sullivan, D. Hsiang, R. Mehta, J. Butler and B. J. Tromberg, “Baseline tumor oxygen saturation correlates with a pathologic complete response in breast cancer patients undergoing neoadjuvant chemotherapy,” Cancer Res., Jul 9. [Epub ahead of print], (2012).
  4. A. E. Cerussi, R. Warren, B. Hill, D. Roblyer, A. Leproux, A. F. Durkin, T. D. O’Sullivan, S. Keene, H. Haghany, T. Quang, W. M. Mantulin and B. J. Tromberg, “Tissue phantoms in multicenter clinical trials for diffuse optical technologies,” Biomed Opt Express 3(5), 966-971, (2012).
  5. L. Meng, W. W. Mantulin, B. S. Alexander, A. E. Cerussi, B. J. Tromberg, Z. Yu, K. Laning, Z. N. Kain, M. Cannesson and A. W. Gelb, “Head-up tilt and hyperventilation produce similar changes in cerebral oxygenation and blood volume: an observational comparison study using frequency-domain near-infrared spectroscopy,” Canadian Journal of Anesthesia/Journal canadien d’anesthésie 59(4), 357-365, (2012).
  6. L. Meng, A. W. Gelb, B. S. Alexander, A. E. Cerussi, B. J. Tromberg, Z. Yu and W. W. Mantulin, “Impact of phenylephrine administration on cerebral tissue oxygen saturation and blood volume is modulated by carbon dioxide in anaesthetized patients,” Br. J. Anaesth. 108(5), 815-822, (2012).



  1. B. Tromberg, A. Cerussi, S. Chung, Tanamai and D. W, A, “Broadband Diffuse Optical Spectroscopy and Imaging,” in Handbook of Biomedical Optics D. Boas, C. Pitris and N. Ramanujam, Eds., CRC Press (2011).
  2. A. Stojadinovic, T. A. Summers, J. Eberhardt, A. Cerussi, W. Grundfest, C. M. Peterson, M. Brazaitis, E. Krupinski and H. Freeman, “Consensus recommendations for advancing breast cancer: risk identification and screening in ethnically diverse younger women,” J Cancer 2, 210-227, (2011).
  3. Y. Santoro, A. Leproux, A. Cerussi, B. Tromberg and E. Gratton, “Breast cancer spatial heterogeneity in near-infrared spectra and the prediction of neoadjuvant chemotherapy response,” J Biomed Opt 16(9), 097007, (2011).
  4. D. Roblyer, S. Ueda, A. Cerussi, W. Tanamai, A. Durkin, R. Mehta, D. Hsiang, J. A. Butler, C. McLaren, W. P. Chen and B. Tromberg, “Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after starting treatment,” Proc Natl Acad Sci U S A 108(35), 14626-14631, (2011).
  5. D. Roblyer, A. Cerussi and B. Tromberg, “Near-Infrared Diffuse Optical Spectroscopic Imaging of Breast Cancer ” in Clinical Spectroscopy J. Tunnell, Ed., McGraw Hill (2011).
  6. L. Meng, M. Cannesson, B. S. Alexander, Z. Yu, Z. N. Kain, A. E. Cerussi, B. J. Tromberg and W. W. Mantulin, “Effect of phenylephrine and ephedrine bolus treatment on cerebral oxygenation in anaesthetized patients,” Br. J. Anaesth. 107(2), 209-217, (2011).
  7. A. Leproux, A. E. Cerussi, W. Tanamai, A. F. Durkin, M. Compton, E. Gratton and B. J. Tromberg, “Impact of contralateral and ipsilateral reference tissue selection on self-referencing differential spectroscopy for breast cancer detection,” J Biomed Opt 16(11), 116019, (2011).
  8. A. E. Cerussi and B. J. Tromberg, “Diffuse Optical Spectroscopy and Imaging in Breast Cancer,” in Optical Detection of Cancer A. D. Meyers, Ed., pp. 135-158, World Scientific Publishing (2011).
  9. A. E. Cerussi, V. W. Tanamai, D. Hsiang, J. Butler, R. S. Mehta and B. J. Tromberg, “Diffuse optical spectroscopic imaging correlates with final pathological response in breast cancer neoadjuvant chemotherapy,” Philos Transact A Math Phys Eng Sci 369(1955), 4512-4530, (2011).



  1. U. Mahmood, A. Cerussi, R. Dehdari, Q. Nguyen, T. Kelley, B. Tromberg and B. Wong, “Near-infrared imaging of the sinuses: preliminary evaluation of a new technology for diagnosing maxillary sinusitis,” J Biomed Opt 15(3), 036011, (2010).
  2. J. Liu, A. Li, A. E. Cerussi and B. J. Tromberg, “Parametric Diffuse Optical Imaging in Reflectance Geometry,” IEEE J Quantum Electron 16(3), 555-564, (2010).
  3. S. Kukreti, A. E. Cerussi, W. Tanamai, D. Hsiang, B. J. Tromberg and E. Gratton, “Characterization of metabolic differences between benign and malignant tumors: high-spectral-resolution diffuse optical spectroscopy,” Radiology 254(1), 277-284, (2010).
  4. S. H. Chung, A. E. Cerussi, S. I. Merritt, J. Ruth and B. J. Tromberg, “Non-invasive tissue temperature measurements based on quantitative diffuse optical spectroscopy (DOS) of water,” Phys. Med. Biol. 55(13), 3753-3765, (2010).
  5. A. E. Cerussi, V. W. Tanamai, R. S. Mehta, D. Hsiang, J. Butler and B. J. Tromberg, “Frequent optical imaging during breast cancer neoadjuvant chemotherapy reveals dynamic tumor physiology in an individual patient,” Acad Radiol 17(8), 1031-1039, (2010).



  1. W. Tanamai, C. Chen, S. Siavoshi, A. Cerussi, D. Hsiang, J. Butler and B. Tromberg, “Diffuse optical spectroscopy measurements of healing in breast tissue after core biopsy: case study,” J Biomed Opt 14(1), 014024, (2009).
  2. D. Jakubowski, F. Bevilacqua, S. Merritt, A. Cerussi and B. Tromberg, “Quantitative Absorption and Scattering Spectra in Thick Tissues using Broadband Diffuse Optical Spectroscopy,” in Biomedical Optical Imaging J. Fujimoto and D. Farkas, Eds., pp. 330-354, Oxford University Press, New York (2009).
  3. A. Cerussi, S. Siavoshi, A. Durkin, C. Chen, W. Tanamai, D. Hsiang and B. J. Tromberg, “Effect of contact force on breast tissue optical property measurements using a broadband diffuse optical spectroscopy handheld probe,” Appl Opt 48(21), 4270-4277, (2009).



  1. B. J. Tromberg, B. W. Pogue, K. D. Paulsen, A. G. Yodh, D. A. Boas and A. E. Cerussi, “Assessing the future of diffuse optical imaging technologies for breast cancer management,” Med. Phys. 35(6), 2443-2451, (2008).
  2. S. H. Chung, A. E. Cerussi, C. Klifa, H. M. Baek, O. Birgul, G. Gulsen, S. I. Merritt, D. Hsiang and B. J. Tromberg, “In vivo water state measurements in breast cancer using broadband diffuse optical spectroscopy,” Phys. Med. Biol. 53(23), 6713-6727, (2008).
  3. K. S. No, R. Kwong, P. H. Chou and A. Cerussi, “Design and testing of a miniature broadband frequency domain photon migration instrument,” J Biomed Opt 13(5), 050509, (2008).
  4. S. Kukreti, A. Cerussi, B. Tromberg and E. Gratton, “Intrinsic near-infrared spectroscopic markers of breast tumors,” Dis Markers 25(6), 281-290, (2008).
  5. A. Li, J. Liu, W. Tanamai, R. Kwong, A. E. Cerussi and B. J. Tromberg, “Assessing the spatial extent of breast tumor intrinsic optical contrast using ultrasound and diffuse optical spectroscopy,” J Biomed Opt 13(3), 030504, (2008).




  1. Li, A., R. Kwong, A. Cerussi, S. Merritt, C. Hayakawa and B. Tromberg, “Method for Recovering Quantitative Broadband Diffuse Optical Spectra from Layered Media,” Appl. Opt. 46(21), 4828-33, (2007).
  2. Lee, J., A. E. Cerussi, D. Saltzman, T. Waddington, B. J. Tromberg and M. Brenner, “Hemoglobin measurement patterns during noninvasive diffuse optical spectroscopy monitoring of hypovolemic shock and fluid replacement,” J Biomed Opt 12(2), 024001, (2007).
  3. Kukreti, S., A. Cerussi, B. Tromberg and E. Gratton, “Intrinsic tumor biomarkers revealed by novel double-differential spectroscopic analysis of near-infrared spectra,” J Biomed Opt 12(2), 020509, (2007).
  4. Cerussi, A., D. Hsiang, N. Shah, M. Compton, R. Mehta, A. F. Durkin and B. Tromberg, “Predicting response to breast cancer neoadjuvant chemotherapy using Diffuse Optical Spectroscopy,” Proc. Natl. Acad. Sci. U. S. A. 104(10), 4014-9, (2007).
  5. Zhou, C., et al., “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J Biomed Opt 12(5), 051903, (2007).



  1. A. Cerussi, N. Shah, D. Hsiang, A. Durkin, J. Butler and B. J. Tromberg, “In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy,” J Biomed Opt 11(4), 044005 (2006)
  2. J. Lee, D. J. Saltzman, A. E. Cerussi, D. V. Gelfand, J. Milliken, T. Waddington, B. J. Tromberg and M. Brenner, “Broadband diffuse optical spectroscopy measurement of hemoglobin concentration during hypovolemia in rabbits,” Physiol. Meas. 27(8), 757-767 (2006)
  3. J. Lee, N. El-Abaddi, A. Duke, A. E. Cerussi, M. Brenner and B. J. Tromberg, “Noninvasive in vivo monitoring of methemoglobin formation and reduction with broadband diffuse optical spectroscopy,” J. Appl. Physiol. 100(2), 615-622 (2006)



  1. B. J. Tromberg, A. Cerussi, N. Shah, M. Compton, A. Durkin, D. Hsiang, J. Butler and R. Mehta, “Imaging in breast cancer: diffuse optics in breast cancer: detecting tumors in pre-menopausal women and monitoring neoadjuvant chemotherapy,” Breast Cancer Res. 7(6), 279-285 (2005)
  2. N. Shah, J. Gibbs, D. Wolverton, A. Cerussi, N. Hylton and B. J. Tromberg, “Combined diffuse optical spectroscopy and contrast-enhanced magnetic resonance imaging for monitoring breast cancer neoadjuvant chemotherapy: a case study,” J Biomed Opt 10(5), 51503 (2005)
  3. D. Hsiang, N. Shah, H. Yu, M. Y. Su, A. Cerussi, J. Butler, C. Baick, R. Mehta, O. Nalcioglu and B. Tromberg, “Coregistration of dynamic contrast enhanced MRI and broadband diffuse optical spectroscopy for characterizing breast cancer,” Technol Cancer Res Treat 4(5), 549-558 (2005)
  4. A. Cerussi, R. Van Woerkom, F. Waffarn and B. Tromberg, “Noninvasive monitoring of red blood cell transfusion in very low birthweight infants using diffuse optical spectroscopy,” J Biomed Opt 10(5), 51401 (2005)
  5. S. H. Tseng, C. Hayakawa, B. J. Tromberg, J. Spanier and A. J. Durkin, “Quantitative spectroscopy of superficial turbid media,” Opt Lett 30(23), 3165-3167 (2005)



  1. N. Shah, A. E. Cerussi, D. Jakubowski, D. Hsiang, J. Butler and B. J. Tromberg, “Spatial variations in optical and physiological properties of healthy breast tissue,” J Biomed Opt 9(3), 534-540 (2004)
  2. D. B. Jakubowski, A. E. Cerussi, F. Bevilacqua, N. Shah, D. Hsiang, J. Butler and B. J. Tromberg, “Monitoring neoadjuvant chemotherapy in breast cancer using quantitative diffuse optical spectroscopy: a case study,” J Biomed Opt 9(1), 230-238 (2004)
  3. N. Shah, A. E. Cerussi, D. Jakubowski, D. Hsiang, J. Butler and B. J. Tromberg, “The role of diffuse optical spectroscopy in the clinical management of breast cancer,” Dis Markers 19(2-3), 95-105 (2003)
  4. S. Merritt, G. Gulsen, G. Chiou, Y. Chu, C. Deng, A. E. Cerussi, A. J. Durkin, B. J. Tromberg and O. Nalcioglu, “Comparison of water and lipid content measurements using diffuse optical spectroscopy and MRI in emulsion phantoms,” Technol Cancer Res Treat 2(6), 563-569 (2003)
  5. S. Merritt, F. Bevilacqua, A. J. Durkin, D. J. Cuccia, R. Lanning, B. J. Tromberg, G. Gulsen, H. Yu, J. Wang and O. Nalcioglu, “Coregistration of diffuse optical spectroscopy and magnetic resonance imaging in a rat tumor model,” Appl Opt 42(16), 2951-2959 (2003)



  1. A. E. Cerussi, D. Jakubowski, N. Shah, F. Bevilacqua, R. Lanning, A. J. Berger, D. Hsiang, J. Butler, R. F. Holcombe and B. J. Tromberg, “Spectroscopy enhances the information content of optical mammography,” J Biomed Opt 7(1), 60-71 (2002)
  2. T. H. Pham, R. Hornung, H. P. Ha, T. Burney, D. Serna, L. Powell, M. Brenner and B. J. Tromberg, “Noninvasive monitoring of hemodynamic stress using quantitative near-infrared frequency-domain photon migration spectroscopy,” J Biomed Opt 7(1), 34-44 (2002)
  3. N. Shah, A. Cerussi, C. Eker, J. Espinoza, J. Butler, J. Fishkin, R. Hornung and B. Tromberg, “Noninvasive functional optical spectroscopy of human breast tissue,” Proc Natl Acad Sci U S A 98(8), 4420-4425 (2001)
  4. A. E. Cerussi, A. J. Berger, F. Bevilacqua, N. Shah, D. Jakubowski, J. Butler, R. F. Holcombe and B. J. Tromberg, “Sources of absorption and scattering contrast for near-infrared optical mammography,” Acad Radiol 8(3), 211-218 (2001)
  5. T. H. Pham, R. Hornung, M. W. Berns, Y. Tadir and B. J. Tromberg, “Monitoring tumor response during photodynamic therapy using near-infrared photon-migration spectroscopy,” Photochem Photobiol 73(6), 669-677 (2001)
  6. B. J. Tromberg, N. Shah, R. Lanning, A. Cerussi, J. Espinoza, T. Pham, L. Svaasand and J. Butler, “Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy,” Neoplasia 2(1-2), 26-40 (2000)
  7. F. Bevilacqua, A. J. Berger, A. E. Cerussi, D. Jakubowski and B. J. Tromberg, “Broadband absorption spectroscopy in turbid media by combined frequency-domain and steady-state methods,” Appl. Opt. 39(34), 6498-6507 (2000)
  8. T. H. Pham, T. Spott, L. O. Svaasand and B. J. Tromberg, “Quantifying the properties of two-layer turbid media with frequency-domain diffuse reflectance,” Appl. Opt. 39(25), 4733-4745 (2000)
  9. T. H. Pham, O. Coquoz, J. B. Fishkin, E. Anderson and B. J. Tromberg, “Broad bandwidth frequency domain instrument for quantitative tissue optical spectroscopy,” Rev. Sci. Instrum. 71(6), 2500-2513 (2000)
  10. M. J. Holboke, B. J. Tromberg, N. Shah, J. Fishkin, D. Kidney, J. Butler, B. Chance and A. G. Yodh, “Three-dimensional diffuse optical mammography with ultrasound localization in a human subject,” J. Biomed. Opt. 5(2), 237-247 (2000)
  11. A. J. Berger, V. Venugopalan, A. J. Durkin, T. Pham and B. J. Tromberg, “Chemometric analysis of frequency-domain photon migration data: quantitative measurements of optical properties and chromophore concentrations in multicomponent turbid media,” Appl. Opt. 39(10), 1659-1667 (2000)


PRE 2000

  1. L. O. Svaasand, T. Spott, J. B. Fishkin, T. Pham, B. J. Tromberg and M. W. Berns, “Reflectance measurements of layered media with diffuse photon-density waves: a potential tool for evaluating deep burns and subcutaneous lesions,” Phys. Med. Biol. 44(3), 801-813 (1999)
  2. R. Hornung, T. H. Pham, K. A. Keefe, M. W. Berns, Y. Tadir and B. J. Tromberg, “Quantitative near-infrared spectroscopy of cervical dysplasia in vivo,” Hum. Reprod. 14(11), 2908-2916 (1999)
  3. B. J. Tromberg, O. Coquoz, J. B. Fishkin, T. Phan, E. R. Anderson, J. Butler, M. Cahn, J. D. Gross, V. Venugopalan and D. Pham, “Non-invasive measurements of breast tissue optical properties using frequency-domain photon migration,” Philos. Trans. R. Soc. Lond. B 352(1354), 661-668 (1997)
  4. J. B. Fishkin, O. Coquoz, E. R. Anderson, M. Brenner and B. J. Tromberg, “Frequency-domain photon migration measurements of normal and malignant tissue optical properties in a human subject,” Appl. Opt. 36(1), 10-20 (1997)
  5. S. J. Madsen, P. Wyss, L. O. Svaasand, R. C. Haskell, Y. Tadir and B. J. Tromberg, “Determination of the optical properties of the human uterus using frequency-domain photon migration and steady-state techniques,” Phys Med Biol 39(8), 1191-1202 (1994)
  6. S. J. Madsen, E. R. Anderson, R. C. Haskell and B. J. Tromberg, “Portable, high-bandwidth frequency-domain photon migration instrument for tissue spectroscopy,” Opt. Lett. 19(23), 1934-1936 (1994)
  7. R. C. Haskell, L. O. Svaasand, T. Tsong-Tseh, F. Ti-Chen, M. S. McAdams and B. J. Tromberg, “Boundary conditions for the diffusion equation in radiative transfer,” J. Opt. Soc. Am. A 11(10), 2727-2741 (1994)
  8. B. J. Tromberg, L. O. Svaasand, T. Tsong-Tseh and R. C. Haskell, “Properties of photon density waves in multiple-scattering media,” Appl. Opt. 32(4), 607-616 (1993)
  9. L. O. Svaasand, B. J. Tromberg, R. C. Haskell, T. Tsong-Tseh and M. W. Berns, “Tissue characterization and imaging using photon density waves,” Opt. Eng. 32(2), 258-266 (1993)